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鹽酸環胞苷
貨號:T1591
產品名稱: 鹽酸環胞苷
英文名: Cyclocytidine hydrochloride
CAS NO.: 10212-25-6
分子式: C9H11N3O4.HCl
分子量: 261.66
產品品牌: targetmol
產品規格: 50mg
鹽酸環胞苷
鹽酸環胞苷抑制劑Ancitabine Hydrochloride is the hydrochloride salt of a cytarabine congener prodrug with antineoplastic activity. Upon administration, ancitabine is slowly hydrolyzed into cytarabine. Subsequently, cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterically hinders the rotation of the molecule within DNA, DNA replication ceases, specifically during the S phase of the cell cycle. Cytarabine agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair. Compared to cytarabine, a more prolonged, consistent cytarabine-mediated therapeutic effect may be achieved with ancitabine because of the slow hydrolytic conversion of ancitabine to cytarabine.
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