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伏立諾他
貨號:T1583
產品名稱: 伏立諾他
英文名: Vorinostat
CAS NO.: 149647-78-9
分子式: C14H20N2O3
分子量: 264.320203781128
產品品牌: targetmol
產品規格: 5mg
伏立諾他
伏立諾他抑制劑Vorinostat is a Histone Deacetylase Inhibitor. Vorinostat is a synthetic hydroxamic acid derivative with antineoplastic activity. This allows the hydroxamic moiety to chelate zinc ion located in the catalytic pockets of HDAC, thereby inhibiting deacetylation and leading to an accumulation of both hyperacetylated histones and transcription factors. Hyperacetylation of histone proteins results in the upregulation of the cyclin-dependent kinase p21, followed by G1 arrest. Hyperacetylation of non-histone proteins such as tumor suppressor p53, alpha tubulin, and heat-shock protein 90 produces additional anti-proliferative effects. This agent also induces apoptosis and sensitizes tumor cells to cell death processes. Vorinostat crosses the blood-brain barrier.
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